As the frequency of internet-based research has increased, it is important for researchers to consider how the conditions in which data are collected may influence the risks to participants. In particular, because internet-based data collection often occurs outside a clinical or research setting, there may be unintentional disclosures of a participant's involvement in a research study of which the researcher is unaware. The current analysis examined the responses of men who have sex with men participating in an internet-based HIV behavioural (...) risk study when queried about the possible disclosure of their participation in the study. Fewer than 2% of participants indicated that their participation in the research study was disclosed, and all but one indicated no negative outcomes associated with the disclosure. As the field of online research continues to expand, it is important to consider risks that are unique to internet-based research, and to monitor these risks to ensure that the confidentiality of research subjects is maintained. (shrink)

BackgroundPatients with COVID-19 may feel under pressure to participate in research during the pandemic. Safeguards to protect research participants include ethical guidelines [e.g. Declaration of Helsinki and good clinical practice (GCP)], legislation to protect participants’ privacy, research ethics committees (RECs) and informed consent. The International Committee of Medical Journal Editors (ICMJE) advises researchers to document compliance with these safeguards. Adherence to publication guidelines has been suboptimal in other specialty fields. The aim of this rapid review was to determine whether COVID-19 (...) human research publications report compliance with these ethical safeguards.MethodsA rapid systematic literature review was conducted in MEDLINE using the search term ‘COVID-19’. The search was performed in April 2020 with no start date and repeated to include articles published in November 2020. Filters were ‘Full free text available’ and ‘English Language’. Two reviewers assessed article title, abstracts and full texts. Non-COVID-19 articles and non-clinical studies were excluded. Independent reviewers conducted a second assessment of a random 20% of articles. The outcomes included reporting of compliance with the Declaration of Helsinki and GCP, REC approval, informed consent and participant privacy.ResultsThe searches yielded 1275 and 1942 articles of which 247 and 717 were deemed eligible, from the April search and November respectively. The majority of journals had editorial policies which purported to comply with ICMJE ethical standards. Reporting of compliance with ethical guidelines was low across all study types but was higher in the November search for case series and observational studies. Reporting of informed consent for case studies and observational studies was higher in the November search, but similar for case series. Overall, participant confidentiality was maintained but some case studies included a combination of details which would have enabled participant identification. Reporting of REC approval was higher in the November search for observational studies.ConclusionsWhile the majority of journal’s editorial policies purported to support the ethical safeguards, many COVID-19 clinical research publications identified in this rapid review lacked documentation of these important safeguards for research participants. In order to promote public trust, ethical declarations should be included consistently. (shrink)

Recent findings emphasize the complexity, both genetic and functional, of the manifold genes and mutations causing inherited retinal degeneration in humans. Knowledge of the genetic bases of these diseases can contribute to design of rational therapy, as well as elucidating the function of each gene product in normal visual processes.

Diseases causing inherited retinal degeneration in humans, such as retinitis pigmentosa and macular dystrophy, are genetically heterogeneous and clinically diverse. More than 40 genes causing retinal degeneration have been mapped to specific chromosomal sites; of these, at least 10 have been cloned and characterized. Mutations in two proteins, rhodopsin and peripherin/RDS, account for approximately 35% of all cases of autosomal dominant retinitis pigmentosa and a lesser fraction of other retinal conditions. This target article reviews the genes and mutations causing retinal (...) degeneration and proposes mechanisms whereby specific mutations lead to particular clinical consequences, that is, the relationship between genotype and phenotype. Retinitis pigmentosa and macular dystrophy are genetically heterogeneous diseases that cause retinal degeneration in humans and often result in severe visual impairment or blindness. Although many of the genes causing these diseases have not been identified, three photoreceptor-specific proteins have been implicated: rhodopsin, peripherin/RDS, and the P-subunit of rod phosphodiesterase. Mutations in the genes for these three proteins can cause either dominant retinitis pigmentosa, recessive retinitis pigmentosa, dominant congenital stationary night blindness, or dominant macular degeneration. Why this multiplicity of clinical phenotypes? Our target article summarizes the genetic and biochemical background to this question and proposes a number of possible explanations. Discussion focuses mainly on 73 distinct disease-causing mutations of rhodopsin. We feel that rhodopsin and other photoreceptor proteins can serve as model systems for unraveling the connection between genotype and phenotype, not only for inherited retinal diseases but for other degenerative disorders as well. (shrink)

Anorexia Nervosa (AN) is widely considered to be a bodily disorder accompanied by unrealistic perceptions about one’s own body. Some researchers thus have wondered whether deficits in interoception, a conscious or non-conscious sense of one’s own body, could be a primary cause of AN. In this paper, we make the case that rather than interoception being a primary cause, deficits in interoception may occur as by-products of emotions that arise upstream in the pathogenesis of AN and interact with feelings of (...) a loss of self-control. We consider interoception, emotion, and self-control as a dynamical triad involved in the explanation of AN, with emotions as the central aspect of their interactions. We begin with a critical analysis of recent empirical literature on AN and differentiate three types of interoceptive processes. We then consider the role of self-control in AN. We go on to evaluate recent empirical and philosophical work on the role of emotions in AN and assess their importance in both interoception and self-control dynamics. We develop a testable integrative model that we believe best captures how self-control, emotional and interoceptive processes causally interact in the pathogenesis of AN. In this model, AN behaviors are not caused by interoceptive abnormalities, but rather interact with changes in emotional regulation and feelings of loss of self-control, subsequently leading to interoceptive deficits downstream. To capture a later stage in the pathogenesis of AN, we show how AN behaviors are maintained as a result of feedback among components in the model. We briefly explain future plans to further complement the model using a semi-structured interview to probe patient perspectives in AN. To develop a more valid understanding of AN, this model will have to be integrated into pluralistic approaches that include patient perspectives. (shrink)

This volume is a collection of original essays focusing on a wide range of topics in the History and Philosophy of Science. It is a festschrift for Peter Machamer, which includes contributions from scholars who, at one time or another, were his students. The essays bring together analyses of issues and debates spanning from early modern science and philosophy through the 21st century. Machamer’s influence is reflected in the volume’s broad range of topics. These include: underdetermination, scientific practice, scientific models, (...) mechanistic explanation in contemporary and historical science, values in science, the relationship between philosophy and psychology, experimentation, supervenience and reductionism. (shrink)

Depression is a widespread concern in the United States. Neuromodulation treatments are becoming more common but there is emerging concern for racial disparities in neuromodulation treatment utilization. This study focuses on Transcranial Magnetic Stimulation (TMS), a treatment for depression, and the structural and attitudinal barriers that racialized individuals face in accessing it. In January 2023 participants from the Twin Cities, Minnesota engaged in focus groups, coupled with an educational video intervention. Individuals self identified as non-white who had no previous TMS (...) exposure but had tried at least one treatment for their depression. Results revealed that the intervention did not notably change knowledge or stigma about TMS, but attitudes surrounding traveling for treatment changed. Notably, barriers like affordability, frequency of treatment, and lack of knowledge persist. Participants expressed a desire for more information, personal connection, and a tailored educational approach. The study suggests a need for multifaceted strategies to reduce disparities, focusing on education, community-based resources, and policy interventions. Immediate actions that can be taken include the creation of a TMS education program focused on patient engagement and awareness about TMS. (shrink)

laudationem ferculum est insecutum plane non pro expectatione magnum: novitas tamen omnium convertit oculos. rotundum enim repositoriurr duodecim habebat signa in orbe disposita, super quae proprium convenien. temque materiae structor imposuerat cibum: super arietem cicer arietinum, super taurum bubulae frustum, super geminos testiculos ac rienes, supei cancrum coronam, super leonem ficum Africanam, super virginem steriliculam super libram stateram in cuius altera parte scriblita erat, in altera placenta super scorpionem † pisciculum marinum, super sagittarium oclopetam, supei capricornum locustam marinam,† super pisces (...) duos mullos. in medio autem caespes cum herbis excisus favum sustinebat. (shrink)

laudationem ferculum est insecutum plane non pro expectatione magnum: novitas tamen omnium convertit oculos. rotundum enim repositoriurr duodecim habebat signa in orbe disposita, super quae proprium convenien. temque materiae structor imposuerat cibum: super arietem cicer arietinum, super taurum bubulae frustum, super geminos testiculos ac rienes, supei cancrum coronam, super leonem ficum Africanam, super virginem steriliculam super libram stateram in cuius altera parte scriblita erat, in altera placenta super scorpionem † pisciculum marinum, super sagittarium oclopetam, supei capricornum locustam marinam,† super pisces (...) duos mullos. in medio autem caespes cum herbis excisus favum sustinebat. (shrink)

A growing group of institutional investors use divestment strategically to deter misconducts that are harmful for the climate and society. Based on Kantian ethics, we propose that divestment represents investors’ universal and absolute moral commitment to socially responsible investing (SRI). Following categorical and hypothetical imperatives and reciprocity as a norm, we hypothesize how institutional investors’ commit to SRI through a divestment strategy against ethically reprehensible behaviour of banks, especially when these investors represent banks themselves. Using a hand-collected database of the (...) revelation dates of enforcement actions on banks, we find evidence that banks are less likely to divest equity holding on banks with misconduct (fined banks) than their non-bank institutional investors peers. Banks that commit to invest responsibly by signing for the Principles for Responsible Investment (PRI) are not significantly more likely to divest on fined banks stocks than non-signatory banks. Moreover, divestment of fined banks whose own legitimacy to operate is in question is not significantly different from non-fined banks divestment. We find that European banks are more inclined to sell their holdings permanently on fined banks than their United States peers. Therefore, bank’s moral commitment to SRI via divestments is influenced more by cultural and reciprocity norms than their moral commitment to participate in the PRI. (shrink)

The most recent commentator on this line, D. R. Shackleton Bailey, states that ‘spiritus is breath rather than odour’ and he has the support of some commentators, Marcilius, for example, who amends notus to motus, and Hertzberg, who takes it as sweet breath, citing Mart. 3. 65. 1. So also most translators : an exception is D. Paganelli who translates ‘aucun souffle, aucune odeur d'adultère’. However, the parallels cited by Shackleton Bailey are irrelevant to this situation: Afranius 243, Ach. Tat. (...) 2. 37. 9, and Claud. Carm. Min. 29. 33 all refer to the period just before, during, or immediately after the sexual act. It is most unlikely that this is the case in Propertius' poem. Propertius has come to see if Cynthia has spent the night alone; it is not a question of catching her inflagrante delicto, but of finding some rival there or the evidence of his stay not yet removed. Cynthia is indignant at her lover's suspicions and lest he should think that his rival had left earlier, she coarsely specifies the evidence that Propertius might expect to find, including spiritus admisso notus adulterio. (shrink)

The most recent commentator on this line, D. R. Shackleton Bailey, states that ‘spiritus is breath rather than odour’ and he has the support of some commentators, Marcilius, for example, who amends notus to motus, and Hertzberg, who takes it as sweet breath, citing Mart. 3. 65. 1. So also most translators : an exception is D. Paganelli who translates ‘aucun souffle, aucune odeur d'adultère’. However, the parallels cited by Shackleton Bailey are irrelevant to this situation: Afranius 243, Ach. Tat. (...) 2. 37. 9, and Claud. Carm. Min. 29. 33 all refer to the period just before, during, or immediately after the sexual act. It is most unlikely that this is the case in Propertius' poem. Propertius has come to see if Cynthia has spent the night alone; it is not a question of catching her inflagrante delicto, but of finding some rival there or the evidence of his stay not yet removed. Cynthia is indignant at her lover's suspicions and lest he should think that his rival had left earlier, she coarsely specifies the evidence that Propertius might expect to find, including spiritus admisso notus adulterio. (shrink)

The uneasiness caused by deberent loqui is reflected in the variant readings and the emendations put forward. Is there in fact a personal subject? To understand iuvenes is possible but clumsy, but if the tragic poets themselves are intended, then these great writers are strangely selfish. Petronius surely is talking about the proper language for good oratory , which depends on a healthy literary language in general. This rules outWilamowitz's too particular and Fuchs's uglier supplements: easier than deceret would be (...) deberet, paralleled almost exactly in Petronius’ contemporary, Seneca . Deberent and deberemus were doubtless due to a desire to provide a personal subject for the misunderstood impersonal verb. (shrink)

The uneasiness caused by deberent loqui is reflected in the variant readings and the emendations put forward. Is there in fact a personal subject? To understand iuvenes is possible but clumsy, but if the tragic poets themselves are intended, then these great writers are strangely selfish. Petronius surely is talking about the proper language for good oratory, which depends on a healthy literary language in general. This rules outWilamowitz's too particular and Fuchs's uglier supplements: easier than deceret would be deberet, (...) paralleled almost exactly in Petronius’ contemporary, Seneca. Deberent and deberemus were doubtless due to a desire to provide a personal subject for the misunderstood impersonal verb. (shrink)

Dōgen has been described as a social reformer based on his more “enlightened” attitude towards women, inviting women students into his sangha and advocating for more egalitarian views of gender (Eido Frances Carney, Receiving the Marrow: Teachings on Dōgen by Soto Zen Women Priests (2012), p. xi). In this chapter, I describe how contemporary Western Zen women and their allies have understood Dōgen’s texts as a tool of personal and social transformation through examination of work by Zen practitioners such as (...) Greenwood’s Bow First (2018), Carney’s Receiving the Marrow (2012), Schireson’s Zen Women (2009), and Glassman and Fields’ Instructions to the Cook (1996). In particular, I posit that Zen women have expressed the practical nature of Dōgen’s philosophy for contemporary non-monastics, showing how to de-center oneself through full participation in the activity of the world. This is in contrast to self-centered preoccupation with individual enlightenment or spiritual attainment. Paradoxically, it is the fact that women have often been confined to social roles that prevent their separation from the minutiae of everyday life that allows them to embody Dōgen’s dictum to “forget the self and be actualized by myriad things.”. (shrink)

When ethics committees are consulted about patients who have or need court-appointed guardians, they lack empirical evidence about several common issues, including the relationship between guardianship and prolonged, potentially medically unnecessary hospitalizations for patients. To provide information about this issue, we conducted quantitative and qualitative analyses using a retrospective cohort from Veterans Healthcare Administration. To examine the relationship between guardianship appointment and hospital length of stay, we first compared 116 persons hospitalized prior to guardianship appointment to a comparison group (n (...) = 348) 3:1 matched for age, diagnosis, date of admission, and comorbidity. We then compared 91 persons hospitalized in the year following guardianship appointment to a second matched comparison group (n = 273). Mean length of stay was 30.75 days (SD = 46.70) amongst those admitted prior to guardianship, which was higher than the comparison group (M = 7.74, SD = 9.71, F = 20.75, p. (shrink)

This thesis develops and defends epistemic fictionalism, according to which knowledge talk is metaphorical. One of the distinctive features of metaphor is that metaphorical sentences have multiple readings: a literal (or ‘face-value’) reading and at least one metaphorical (or ‘non-face-value’) reading. Typically, speakers who utter metaphorical sentences intend to communicate a content that corresponds to the metaphorical meaning. Epistemic fictionalism posits that, as is standard for metaphors, sentences of the form “S knows that P” admit of at least two different (...) readings: a face-value (literal) reading, and a different non-face-value metaphorical reading. A face-value reading of sentences of the form “S knows that P” is that S is infallible with regards to P, and as such are always (or almost always) false at face-value. However, such sentences are not typically used to communicate their typically false face-value content, but some other, typically true metaphorical content. The thesis applies the methods of function-first epistemology (Craig 1990, Hannon 2019a), taking as a starting point the question of what knowledge talk is used for. I argue that understanding knowledge talk as metaphorical coheres with the function that knowledge talk plays, in spite of all (or most) knowledge attributions being literally false: there are advantages to communicating the non-face-value, metaphorical content. Another key advantage of epistemic fictionalism is that it explains the intuitions surrounding sceptical arguments. On the one hand, sceptical infallibilism is compelling because it is the correct analysis of the face-value content of knowledge attributions. On the other hand, sceptical infallibilism is not threatening to everyday knowledge attributions because it does not threaten the truth of the metaphorical content that knowledge attributions are typically used to express. Overall, the main aim of the thesis is to motivate epistemic fictionalism as a serious contender worthy of further investigation and development. (shrink)

In this paper we argue that Steglich-Petersen’s response to Owens’ Exclusivity Objection does not work. Our first point is that the examples Steglich-Petersen uses to demonstrate his argument do not work because they employ an undefended conception of the truth aim not shared by his target (and officially eschewed by Steglich-Petersen himself). Secondly we will make the point that deliberating over whether to form a belief about p is not part of the belief forming process. When an agent enters into (...) this process of deliberation, he has not, contra Steglich-Petersen, already adopted the truth aim with regard to p. In closing, we further suggest that proponents of the truth aim hypothesis need to focus on aim-guidance, not mere aim attribution, for their approach to have explanatory utility so underlining the significance of Owens’ argument. (shrink)

In The Racial Contract, Charles Mills introduces the notion of an ‘inverted epistemology,’ an epistemology that construes social and racial ignorance as knowledge (p.18). As Mills points out, such ignorance can be used to oppress people by creating alternate realities or ‘white mythologies’ about race (p. 19). If the racial contract results in a society that oppresses people of color and supports white supremacy, then the question of how to correct an inverted epistemology becomes critical. Mills proposes the correction of (...) history and the racist thinking underwriting it as a solution to the problem. Others, like Alison Bailey, seek to confront racial ignorance with active resistance by suggesting that individuals from historically marginalized groups exploit what members of dominant society don’t know (p. 77). While Bailey’s solution, referred to as strategic ignorance, may originate from good intentions, I argue that it is in general inappropriate for Indigenous people. Strategic ignorance is a product of the Western worldview, and it privileges Western values. In fact, both solutions offered by Mills and Bailey fail to consider Indigenous values. Mills’ proposed solution, however, is less objectionable. Instead of either solution, a more suitable form of resistance – one that embraces connectedness, balance, and harmony – would be ideal for the Indigenous communities of Turtle Island. (shrink)

My point of departure is a passage in which Coffa claims: “Wittgenstein’s and Carnap’s insights on the a priori belong in the same family as Kant’s... What we witness circa 1930 is a Copernican turn that, like Kant’s, bears the closest connection to the a priori; but its topic is meaning rather than experience” [Coffa, 1991, p. 263]. I draw out Kantian resonances in Wittgenstein’s and Carnap’s work on logic, grammar, and theoretical frameworks. In the end, Coffa’s remark comes out (...) as significantly illuminating for a variety of questions, issues, and dynamic historical trends. (shrink)

Chapter Promising in Law and Morals Promissory and contractual obligations raise many issues of common interest to philosophers and lawyers. ...

In recent years "British" Idealism has been subject to sweeping re-evaluation and rehabilitation. The essays collected here by Will Sweet compare Bernard Bosanquet's ideas and arguments with those of Idealists and non-Idealists alike, and establish that Bosanquet was far more clear-headed and insightful than denunciations of the "Idealist school" by Moore, Russell, C. D. Broad, Harold Prichard, and A. J. Ayer suggest. Sweet observes in his introduction that Bosanquet has long remained in the shadows of T. H. Green and F. (...) H. Bradley, that Bosanquet was a prolific writer who shaped philosophical debates across the English-speaking world for decades, and that estimations of his social theory and political philosophy, and to a lesser extent his metaphysics, have diverted attention from his contributions to logic and aesthetics.Essays by Sandra M. den Otter, Peter Nicholson, and Kevin Sullivan deal directly with Bosanquet's social philosophy. Bosanquet was engaged from the 1880s in work with the Charity Organisation Society, an association that set the tone of late Victorian and Edwardian debates over British poverty. He and his wife served on the Royal Commission on the Poor Laws , against whose majority statement—cautioning against such direct assistance to the poor as. (shrink)